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Escherichia coli: Chapter 17. Capsule and lipopolysaccharide

Chris Whitfield

0/5 ( ratings)

Escherichia coli isolates produce a range of cell-surface polysaccharides which mediate interactions between the bacteria and their environment. The best-studied glycoconjugates are lipopolysaccharide and capsular polysaccharide . LPS is a component of the outer membrane in all E. coli strains and it plays a critical role in the barrier properties of the cell envelope and resistance to host factors including cationic antimicrobial peptides and the complement system. LPS is also a biologically active molecule that activates TLR4-mediated signaling leading to endotoxic shock. In contrast, only some strains of E. coli make capsular polysaccharides . The capsule plays a major role in evasion of the host immune system and is particularly important for the pathogenesis of uropathogenic and meningitis-associated E. coli. This chapter discusses the biosynthesis of LPS and capsule as well as their contributions to the virulence of pathogenic E. coli.

Language: English

Pages: 49

Format: Kindle Edition

Release: June 12, 2013

Escherichia coli: Chapter 17. Capsule and lipopolysaccharide

Chris Whitfield

0/5 ( ratings)

Escherichia coli isolates produce a range of cell-surface polysaccharides which mediate interactions between the bacteria and their environment. The best-studied glycoconjugates are lipopolysaccharide and capsular polysaccharide . LPS is a component of the outer membrane in all E. coli strains and it plays a critical role in the barrier properties of the cell envelope and resistance to host factors including cationic antimicrobial peptides and the complement system. LPS is also a biologically active molecule that activates TLR4-mediated signaling leading to endotoxic shock. In contrast, only some strains of E. coli make capsular polysaccharides . The capsule plays a major role in evasion of the host immune system and is particularly important for the pathogenesis of uropathogenic and meningitis-associated E. coli. This chapter discusses the biosynthesis of LPS and capsule as well as their contributions to the virulence of pathogenic E. coli.

Language: English

Pages: 49

Format: Kindle Edition

Release: June 12, 2013

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