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Membrane Alterations in Cancer

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In recent years much attention has been paid to cell membrane alterations associ ated with transformation and malignancy. Alterations of tumor cell membrane have been demonstrated in terms of cell biology, such as increased agglutinability of tumor cells with lectins and elevation of sugar transport across the membrane. Changes in the car bohydrate chains of cell surface glycoproteins and glycolipids probably ascribable to quantitative and qualitative shifts of synthetic and possibly degradative enzymes have been extensively studied. Some enzymes which are localized on the cell surface are shed into the circulation of cancer patients, and are of potential clinical value. While it is clear that new insights into a number of problems have been generated, we still do not understand the mechanisms by which changes at the level of the genome bring about membrane changes and how these in turn are the basis for the cancer phe notype: autonomous growth, metastasis, and altered differentiation and function."

Language: English

Pages: 303

Format: Hardcover

Publisher: Springer

Release: October 01, 1983

ISBN: 0306415658

ISBN 13: 9780306415654

Membrane Alterations in Cancer

0/5 ( ratings)

In recent years much attention has been paid to cell membrane alterations associ ated with transformation and malignancy. Alterations of tumor cell membrane have been demonstrated in terms of cell biology, such as increased agglutinability of tumor cells with lectins and elevation of sugar transport across the membrane. Changes in the car bohydrate chains of cell surface glycoproteins and glycolipids probably ascribable to quantitative and qualitative shifts of synthetic and possibly degradative enzymes have been extensively studied. Some enzymes which are localized on the cell surface are shed into the circulation of cancer patients, and are of potential clinical value. While it is clear that new insights into a number of problems have been generated, we still do not understand the mechanisms by which changes at the level of the genome bring about membrane changes and how these in turn are the basis for the cancer phe notype: autonomous growth, metastasis, and altered differentiation and function."

Language: English

Pages: 303

Format: Hardcover

Publisher: Springer

Release: October 01, 1983

ISBN: 0306415658

ISBN 13: 9780306415654

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